Anaphylactic Reaction Caused by Co-administration of Diclofenac and Ofloxacin
Abstract
Anaphylaxis is the most severe form of an allergic reaction. Drug-induced anaphylaxis can be life-threatening after drug intake by any route, including non-therapeutic exposure due to accidental contact. The most common culprit drugs are non-steroidal anti-inflammatory drugs, beta-lactam antibiotics and other antibiotics such as quinolones. A 25-year-old female patient attended the dental clinic with the complaint of toothache and was prescribed Diclofenac 50 mg and Ofloxacin 200 mg twice a day. After a day patient was brought to the Emergency and Trauma Centre of the hospital with multiple erythematous macules and papules over both forearms, multiple erythematous macules present over trunk, itching over the lesions, fever and throat pain. The patient was diagnosed as a case of Anaphylactic Reaction associated with the co-administration of Diclofenac and Ofloxacin. Drugs were discontinued on the same day, and further management was started. The causality assessment of this case was possible as per the WHO-UMC causality assessment scale